Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.

doi:10.1093/hmg/dds273

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Article

Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.

Human molecular genetics - 15 Oct 2012

Bader Verian, Tomppo Liisa, Trossbach Svenja V, Bradshaw Nicholas J, Prikulis Ingrid, Leliveld S Rutger, Lin Chi-Ying, Ishizuka Koko, Sawa Akira, Ramos Adriana, Rosa Isaac, García Ángel, Requena Jesús R, Hipolito Maria, Rai Narayan, Nwulia Evaristus, Henning Uwe, Ferrea Stefano, Luckhaus Christian, Ekelund Jesper, Veijola Juha, Järvelin Marjo-Riitta, Hennah William, Korth Carsten

Abstract excerpt

Schizophrenia is a chronic illness of heterogenous biological origin. We hypothesized that, similar to chronic progressive brain conditions, persistent functional disturbances of neurons would result in disturbed proteostasis in the brains of schizophrenia patients, leading to increased abundance of specific misfolded, insoluble proteins. Identification of such proteins would facilitate the elucidation of...

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Identifiers

PMID: 22798627
DOI: 10.1093/hmg/dds273
PMCID: PMC3529585

Genes

CRMP1
DISC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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