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Article

Aggregated proteins in schizophrenia and other chronic mental diseases

1 Apr 2012

Abstract excerpt

Chronic mental diseases (CMD) like the schizophrenias are progressive diseases of heterogenous but poorly understood biological origin. An imbalance in proteostasis is a hallmark of dysfunctional neurons, leading to impaired clearance and abnormal deposition of protein aggregates. Thus, it can be hypothesized that unbalanced proteostasis in such neurons may also lead to protein aggregates in schizophrenia. These...

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PMID: 22421208
DOI: 10.4161/pri.18989

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