Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease

Abstract excerpt

Neurodegenerative disorders progress across the brain in characteristic spatio-temporal patterns. A better understanding of the factors underlying the specific cell and tissue vulnerability responsible for such patterns could help identify the molecular origins of these conditions. To investigate these factors, based on the observation that neurodegenerative disorders are closely associated with the presence of...

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