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Protein Aggregation of NPAS3, Implicated in Mental Illness, Is Not Limited to the V304I Mutation

23 Oct 2021

Abstract excerpt

An emerging phenomenon in our understanding of the pathophysiology of mental illness is the idea that specific proteins may form insoluble aggregates in the brains of patients, in partial analogy to similar proteinopathies in neurodegenerative diseases. Several proteins have now been detected as forming such aggregates in the brains of patients, including DISC1, dysbindin-1 and TRIOBP-1. Recently, neuronal PAS...

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PMID: 34834422
DOI: 10.3390/jpm11111070

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