Article

Succinate Dehydrogenase Subunit B Regulates Cisplatin Resistance via DNA Damage in Human Ovarian Cancer Cells

2022-03-21

Abstract excerpt

<h4>Background: </h4> Succinate dehydrogenase subunit B (SDHB) is one of succinate dehydrogenase subunits which is an important enzyme in the tricarboxylic acid (TCA) cycle. SDHB has been found expressed low in human ovarian carcinoma compared to human ovarian normal epithelium tissues. Previous studies have confirmed that the high expression of SDHB significantly inhibits the proliferation, invasion and migration...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f65c5bd-a9bf-555e-8808-81a7ecb73489
DOI: 10.21203/rs.3.rs-1458729/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Succinate Dehydrogenase Subunit B Regulates Cisplatin Resistance via DNA Damage in Human Ovarian Cancer CellsDOI 10.21203/rs.3.rs-1458729/v1Read

SDHB reduces chemotherapy resistance in ovarian cancer cells by affecting epithelial mesenchymal transition through DNA damage repairSemantic proximity Read

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian CancerSemantic proximity Read

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolismSemantic proximity Read

Exploring the critical role of SDHA in breast cancer proliferation: implications for novel therapeutic strategiesSemantic proximity Read

SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting GlycolysisSemantic proximity Read

Genetic, epigenetic and biochemical regulation of succinate dehydrogenase functionSemantic proximity Read

Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors.Semantic proximity Read

Unveiling the hidden role of SDHA in breast cancer proliferation: a novel therapeutic avenueSemantic proximity Read

ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling.Semantic proximity Read

Single nucleotide variants of succinate dehydrogenase A gene in renal cell carcinoma.Semantic proximity Read

Cells silenced for SDHB expression display characteristic features of the tumor phenotype.Semantic proximity Read

Overexpression of DDB2 enhances the sensitivity of human ovarian cancer cells to cisplatin by augmenting cellular apoptosisSemantic proximity Read