Article

SDHB reduces chemotherapy resistance in ovarian cancer cells by affecting epithelial mesenchymal transition through DNA damage repair

2024-05-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Ovarian carcinoma is one of the most common gynecological cancers with high mortality rates. Succinate dehydrogenase (SDH or Complex II) which is one of the important enzymes in the tricarboxylic acid (TCA) cycle plays an important role in carcinomas. Succinate dehydrogenase subunit B (SDHB) gene, which encodes one of the four subunits of SDH, has been found pla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f12814b-9316-5c0f-a243-ae49c7c4d2a5
DOI: 10.21203/rs.3.rs-4383549/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SDHB reduces chemotherapy resistance in ovarian cancer cells by affecting epithelial mesenchymal transition through DNA damage repairDOI 10.21203/rs.3.rs-4383549/v1Read

Succinate Dehydrogenase Subunit B Regulates Cisplatin Resistance via DNA Damage in Human Ovarian Cancer CellsSemantic proximity Read

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolismSemantic proximity Read

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian CancerSemantic proximity Read

SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting GlycolysisSemantic proximity Read

Exploring the critical role of SDHA in breast cancer proliferation: implications for novel therapeutic strategiesSemantic proximity Read

Cells silenced for SDHB expression display characteristic features of the tumor phenotype.Semantic proximity Read

PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinomaSemantic proximity Read

Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting PI3K/AKT Pathway and Activating AMPK/ROS PathwaySemantic proximity Read

Unveiling the hidden role of SDHA in breast cancer proliferation: a novel therapeutic avenueSemantic proximity Read

[Expression of succinate dehydrogenase subunit protein in succinate dehydrogenase-deficient gastrointestinal stromal tumors].Semantic proximity Read

ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling.Semantic proximity Read

PGC1α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cellsSemantic proximity Read