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Article

Single nucleotide variants of succinate dehydrogenase A gene in renal cell carcinoma.

Cancer science - 1 Aug 2021

Kamai Takao, Higashi Satoru, Murakami Satoshi, Arai Kyoko, Namatame Takashi, Kijima Toshiki, Abe Hideyuki, Jamiyan Tsengelmaa, Ishida Kazuyuki, Shirataki Hiromichi, Yoshida Ken-Ichiro

Abstract excerpt

Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is mainly associated with a mutation in the SDHB gene and sometimes with mutations in the SDHC or SDHD genes. However, only three cases of succinate dehydrogenase A (SDHA)-deficient RCC have been reported, and the relation between SDHA mutations and RCC has not been clarified. This study assessed the role of SDHA gene mutations in human RCC. We...

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Source

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Identifiers

PMID: 34014604
DOI: 10.1111/cas.14977
PMCID: PMC8353944

Genes

SDHA
SDHB
SDHC
SDHD

Provenance

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