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Article

ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling.

PloS one - 1 Jan 2014

Meng Erhong, Mitra Aparna, Tripathi Kaushlendra, Finan Michael A, Scalici Jennifer, McClellan Steve, Madeira da Silva Luciana, Reed Eddie, Shevde Lalita A, Palle Komaraiah, Rocconi Rodney P

Abstract excerpt

OBJECTIVE: Aldehyde dehydrogenase (ALDH) expressing cells have been characterized as possessing stem cell-like properties. We evaluated ALDH+ ovarian cancer stem cell-like properties and their role in platinum resistance. METHODS: Isogenic ovarian cancer cell lines for platinum sensitivity (A2780) and platinum resistant (A2780/CP70) as well as ascites from ovarian cancer patients were analyzed for ALDH+ by flow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25216266
DOI: 10.1371/journal.pone.0107142
PMCID: PMC4162571

Genes

BAX
BRCA1
FANCD2
KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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