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Article

Unveiling the hidden role of SDHA in breast cancer proliferation: a novel therapeutic avenue

21 Mar 2025

Abstract excerpt

BACKGROUND: We observed an increased presence of succinate dehydrogenase complex subunit A (SDHA), a mitochondrial enzyme, in breast cancer (BC), which contributes to its proliferation. While SDHA deficiency has been extensively researched in rare disorders, the upregulation of SDHA and its impact on BC remain understudied. The aim of this study is to investigate the role of SDHA in BC. METHODS: The mRNA...

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PMID: 40119440
DOI: 10.1186/s12935-025-03746-6

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