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Article

Role of the Unfolded Protein Response in<i>β</i>Cell Compensation and Failure during Diabetes

1 Jan 2014

Abstract excerpt

Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt their secretory capacity to compensate the elevated glycaemia and the peripheral insulin resistance. This compensatory mechanism involves a fine-tuned regulation to modulate the endoplasmic reticulum (ER) capacity and quality control to prevent unfolded proinsulin accumulation, a major protein synthetized within the...

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PMID: 24812634
DOI: 10.1155/2014/795171

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