Article
A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice.
Gut - 7 Aug 2025
Bodas Cristina, Felipe Irene, Chanez Brice, Lafarga Miguel, Lopez de Maturana Evangelina, Martinez de Villarreal Jaime, Del Pozo Natalia, Malumbres Marina, Vargiu Pierfrancesco, Cayuela Ana, Peset Isabel, Connelly Katelyn, Hoskins Jason, Méndez Raúl, Amundadottir Laufey, Malats Núria, Ortega Sagrario, Real Francisco X
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified an exon 6 CTRB2 deletion variant proposed to increase pancreatic cancer risk. OBJECTIVE: To acquire evidence on its causal role, we developed and analysed a new mouse strain carrying an equivalent variant in Ctrb1, the mouse CTRB2 orthologue. DESIGN: We used CRISPR/Cas9 to introduce a 707 bp deletion encompassing Ctrb1 exon 6 (Ctrb1Δexon6 ). This...
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