Article

Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin Resistance

2026-04-01

Abstract excerpt

Insulin resistance (IR) is a key driver of cardiometabolic disease, yet its genetic and regulatory architecture remains incompletely understood. We performed a multi-trait GWAS of fasting insulin, triglycerides, and HDL cholesterol (n ≤ 1.25 million), identifying 282 IR-associated loci, including 70 novel. Polygenic score analyses linked IR to an adverse fat distribution characterized by reduced subcutaneous and i...

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Literature Corpus work: 505e2b2d-8810-5975-bb17-b97acaa4dd79
DOI: 10.64898/2026.03.31.26349822

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