Article
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease.
EBioMedicine - 1 Aug 2024
Lee Seung Hyuk T, Garske Kristina M, Arasu Uma Thanigai, Kar Asha, Miao Zong, Alvarez Marcus, Koka Amogha, Darci-Maher Nicholas, Benhammou Jihane N, Pan David Z, Örd Tiit, Kaminska Dorota, Männistö Ville, Heinonen Sini, Wabitsch Martin, Laakso Markku, Agopian Vatche G, Pisegna Joseph R, Pietiläinen Kirsi H, Pihlajamäki Jussi, Kaikkonen Minna U, Pajukanta Päivi
Abstract excerpt
BACKGROUND: Abdominal obesity increases the risk for non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: To elucidate the directional cell-type level biological mechanisms underlying the association between abdominal obesity and MASLD, we integrated adipose and liver single nucleus RNA-sequencing and bulk cis-expression quantitative...
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