Article

H3.1 <sup>Cys96</sup> oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance

2022-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Transcription stability enforces cellular identity and is tightly controlled by restrictions imposed on both transcription factor function and target gene accessibility. Progression of cancer to metastasis and multi-drug resistance requires fluid transcriptional programs that can explore different genomic landscapes to enable clonal expansion of aggressive and treatment resistant phenotypes. Her...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f3033c8-292d-51ae-b536-1f810977d036
DOI: 10.1101/2022.12.01.517361

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

H3.1 <sup>Cys96</sup> oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistanceDOI 10.1101/2022.12.01.517361Read

Epithelial-mesenchymal transition and H<sub>2</sub>O<sub>2</sub> signaling – a driver of disease progression and a vulnerability in cancersSemantic proximity Read

Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic LiaisonSemantic proximity Read

Reduction of LOXL2-mediated H3K4 oxidation increases chromatin accessibility and promotes chemosensitivity of triple-negative breast cancer cellsSemantic proximity Read

p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress.Semantic proximity Read

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasisSemantic proximity Read

Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype.Semantic proximity Read

H2A.Z-dependent and -independent recruitment of metabolic enzymes to chromatin required for histone modificationsSemantic proximity Read

Structure of Nm23-H1 under oxidative conditions.Semantic proximity Read

Redox signaling regulates breast cancer metastasis via HIF1α-stimulated EMT dynamics and metabolic reprogrammingSemantic proximity Read

Epigenetic coordination of transcriptional and translational programs in hypoxiaSemantic proximity Read

Heterogeneous adaptation of cysteine reactivity to a covalent oncometaboliteSemantic proximity Read

Hydrogen Peroxide induces resistance to DNA damage in a localization and p53 dependent mannerSemantic proximity Read