Article

Reduction of LOXL2-mediated H3K4 oxidation increases chromatin accessibility and promotes chemosensitivity of triple-negative breast cancer cells

2018-09-13

Abstract excerpt

Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase–like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) cell lines and patient–derived xenographs (PDXs) than those from other breast cancer subtypes. ChIP-seq revealed that H3K4ox is located primarily in heterochromatin, where it is involved in chromati...

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Literature Corpus work: 8eff51d2-330c-5a35-aee0-5ff53ba152e8
DOI: 10.1101/416495

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