Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of Nm23-H1 under oxidative conditions.

Acta crystallographica. Section D, Biological crystallography - 1 Apr 2013

Kim Mi-Sun, Jeong Jaeho, Jeong Jihye, Shin Dong-Hae, Lee Kong-Joo

Abstract excerpt

Nm23-H1/NDPK-A, a tumour metastasis suppressor, is a multifunctional housekeeping enzyme with nucleoside diphosphate kinase activity. Hexameric Nm23-H1 is required for suppression of tumour metastasis and it is dissociated into dimers under oxidative conditions. Here, the crystal structure of oxidized Nm23-H1 is presented. It reveals the formation of an intramolecular disulfide bond between Cys4 and Cys145 that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Linking Reagents
Share to Crystallography, X-Ray
Share to Cysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disulfides

Share to Molecular Dynamics Simulation

Share to NM23 Nucleoside Diphosphate Kinases

Share to Oxidative Stress

Share to Protein Stability

Source

Identifiers

PMID: 23519676
DOI: 10.1107/S0907444913001194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of Nm23-H1 under oxidative conditions.PMID 23519676Read ↗

Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction.Semantic proximity Read ↗

Toward an Understanding Of the Structural and Mechanistic Aspects of Protein-Protein Interactions in 2-Oxo Acid Dehydrogenase ComplexesSemantic proximity Read ↗

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme DimerSemantic proximity Read ↗

The crystal structure of a human nucleoside diphosphate kinase, NM23-H2.Semantic proximity Read ↗

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolismSemantic proximity Read ↗

Multiple biochemical activities of NM23/NDP kinase in gene regulation.Semantic proximity Read ↗

Seesaw Conformations of Npl4 in the Human p97 Complex and the Inhibitory Mechanism of a Disulfiram DerivativeSemantic proximity Read ↗

H3.1 <sup>Cys96</sup> oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistanceSemantic proximity Read ↗

Functional Integrity of Radical SAM Enzyme Dph1•Dph2 Requires Non-canonical Cofactor Motifs with Tandem CysteinesSemantic proximity Read ↗

Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria.Semantic proximity Read ↗

The Atomic Resolution Structure of Human AlkB Homolog 7 (ALKBH7), a Key Protein for Programmed Necrosis and Fat MetabolismSemantic proximity Read ↗

Biochemical and biophysical properties of the novel ALS-linked hSOD1 mutants: an experimental study accompanied by in silico analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.