Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison

Abstract excerpt

Conversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage. Cancer cells are located in a very complex microenvironment together with stromal components that participate to enhance oxidative stress to promote tumor progression. Indeed, convincing experimental and clinical evidence underline the key role of...

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