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Article

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

3 Apr 2017

Abstract excerpt

By causing mitochondrial DNA (mtDNA) mutations and oxidation of mitochondrial proteins, reactive oxygen species (ROS) leads to perturbations in mitochondrial proteostasis. Several studies have linked mtDNA mutations to metastasis of cancer cells but the nature of the mtDNA species involved remains unclear. Our data suggests that no common mtDNA mutation identifies metastatic cells; rather the metastatic potential...

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PMID: 28368421
DOI: 10.1038/onc.2017.52

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