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Article

Engineered human soluble calcium-activated nucleotidase inhibits coagulation in vitro and thrombosis in vivo.

Thrombosis research - 1 Jan 2008

Yang Mingyan, Kirley Terence L

Abstract excerpt

Human soluble calcium-activated nucleotidase (human SCAN) is a homologue of the salivary anti-coagulant apyrases injected by insects into their hosts to allow blood feeding. However, the human enzyme, unlike its insect counterparts, does not efficiently hydrolyze the platelet agonist, ADP. By site-directed mutagenesis, two mutant human SCANs were constructed and expressed in bacteria. Following refolding from...

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Identifiers

PMID: 18222531
DOI: 10.1016/j.thromres.2007.12.002
PMCID: PMC2561175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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