Article
An overview of the heparin-induced thrombocytopenia syndrome.
Seminars in thrombosis and hemostasis - 1 Jun 2004
Warkentin Theodore E
Abstract excerpt
Heparin-induced thrombocytopenia (HIT) is caused by heparin-dependent, platelet-activating IgG antibodies that increase thrombin generation in vivo, producing a prothrombotic phenotype. In addition to platelet activation, there is in vitro evidence that activation of endothelium and monocytes occurs, perhaps directly by HIT antibodies, but more likely through activated platelet (or...
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