Article

Thymidine Phosphorylase Mediates SARS-CoV-2 Spike Protein Enhanced Thrombosis in K18-hACE2 <sup>TG</sup> Mice

2024-02-23

Abstract excerpt

COVID-19, caused by SARS-CoV-2, is associated with arterial and venous thrombosis, thereby increasing mortality. SARS-CoV-2 spike protein (SP), a viral envelope structural protein, is implicated in COVID-19-associated thrombosis. However, the underlying mechanisms remain unknown. Thymidine phosphorylase (TYMP), a newly identified prothrombotic protein, is upregulated in the plasma, platelets, and lungs of patients...

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Literature Corpus work: fb8e07b7-c9d0-5494-b721-f4095e9a751a
DOI: 10.1101/2024.02.23.581661

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