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Article

Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk

24 Dec 2023

Abstract excerpt

ABSTRACT: JAK2 V617F (JAK2VF) clonal hematopoiesis (CH) has been associated with atherothrombotic cardiovascular disease (CVD). We assessed the impact of Jak2VF CH on arterial thrombosis and explored the underlying mechanisms. A meta-analysis of 3 large cohort studies confirmed the association of JAK2VF with CVD and with platelet counts and adjusted mean platelet volume (MPV). In mice, 20% or 1.5% Jak2VF CH...

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Identifiers

PMID: 38142422
DOI: 10.1182/blood.2023022260

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