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Article

Paclitaxel improves thrombopoiesis in the absence of thrombopoietin receptor (Mpl).

Journal of thrombosis and haemostasis : JTH - 1 Dec 2024

Meng Panpan, Liu Wenyu, Lao Jiawen, Liu Xunwei, Zhang Yangping, Sun Ying, Zhou Riyang, Du Changhong, Wang Junping, Zhao Dejian, Lin Qing, Zhang Yiyue

Abstract excerpt

BACKGROUND: Platelets are critical for thrombosis and hemostasis. The THPO-MPL pathway is the primary pathway for generating thrombocytes. Dysregulation of thrombopoiesis results in platelet formation and/or function-related disorders, such as thrombocytopenia. Paclitaxel is an extensively utilized chemotherapeutic agent and its activity may be related to platelets, but the effect of paclitaxel on...

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Source

Identifiers

PMID: 39307245
DOI: 10.1016/j.jtha.2024.08.025

Genes

JAK2
MPL
THPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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