Article

Specific mutations in genes responsible for Alzheimer and for Duchenne Muscular Dystrophy introduced by Base editing and PRIME editing

2020-08-01

Abstract excerpt

<h4>ABSTRACT</h4> Base editing technique and PRIME editing techniques derived from the CRISPR/Cas9 discovery permit to modify selected nucleotides. We initially used the base editing technique to introduce in the APP gene the A673T mutation, which prevents the development of Alzheimer’s disease. Although the desired cytidine to thymidine mutation was inserted in up to 17% of the APP gene in HEK393T, there were...

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Literature Corpus work: 561d92ef-21c5-52d1-811b-a2831007aeed
DOI: 10.1101/2020.07.31.230565

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