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Article

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I).

Stem cell research - 1 May 2021

Hernández Damián, Morgan Schlicht Stephanie, Daniszewski Maciej, Karch Celeste M, Goate Alison M, Pébay Alice

Abstract excerpt

We report the genome-editing of an existing iPSC line carrying the London mutation in APP (V717I) into an iPSC line in which the pathogenic mutation was corrected. The resulting isogenic iPSC line maintained pluripotent stem cell morphology, a normal karyotype, expression of pluripotency markers and the ability to differentiate into the three germ-layers in vitro.

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Identifiers

PMID: 34088002
DOI: 10.1016/j.scr.2021.102373
PMCID: PMC10084742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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