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Integrative analysis reveals early epigenetic alterations in high-grade serous ovarian carcinomas

2 Oct 2023

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological malignancy. To date, the profiles of gene mutations and copy number alterations in HGSOC have been well characterized. However, the patterns of epigenetic alterations and transcription factor dysregulation in HGSOC have not yet been fully elucidated. In this study, we performed integrative omics analyses of a series of stepwise HGSOC...

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PMID: 37779141
DOI: 10.1038/s12276-023-01090-1

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