Article
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes.
Nature genetics - 1 Feb 2015
Leiserson Mark D M, Vandin Fabio, Wu Hsin-Ta, Dobson Jason R, Eldridge Jonathan V, Thomas Jacob L, Papoutsaki Alexandra, Kim Younhun, Niu Beifang, McLellan Michael, Lawrence Michael S, Gonzalez-Perez Abel, Tamborero David, Cheng Yuwei, Ryslik Gregory A, Lopez-Bigas Nuria, Getz Gad, Ding Li, Raphael Benjamin J
Abstract excerpt
Cancers exhibit extensive mutational heterogeneity, and the resulting long-tail phenomenon complicates the discovery of genes and pathways that are significantly mutated in cancer. We perform a pan-cancer analysis of mutated networks in 3,281 samples from 12 cancer types from The Cancer Genome Atlas (TCGA) using HotNet2, a new algorithm to find mutated subnetworks that overcomes the limitations of existing...
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