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Article

Pan-cancer landscape of epigenetic factor expression predicts tumor outcome

16 Nov 2023

Abstract excerpt

Oncogenic pathways that drive cancer progression reflect both genetic changes and epigenetic regulation. Here we stratified primary tumors from each of 24 TCGA adult cancer types based on the gene expression patterns of epigenetic factors (epifactors). The tumors for five cancer types (ACC, KIRC, LGG, LIHC, and LUAD) separated into two robust clusters that were better than grade or epithelial-to-mesenchymal...

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PMID: 37973839
DOI: 10.1038/s42003-023-05459-w

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