Article

Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

2023-08-05

Abstract excerpt

Allergic asthma is a disease driven by T helper 2 (Th2) cells, eosinophilia, airway hyperresponsiveness (AHR) and IgE-secreting B cells. Asthma is largely controlled by corticosteroids and β 2 adregenic receptor agonists that target and relax airway smooth muscle (ASM). Immunoglobulin M (IgM) isotype secreted by naïve B cells is important for class switching but may have other undefined functions. We investigated...

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Literature Corpus work: 0f05732c-5765-526f-ab75-aadd4ad07d23
DOI: 10.1101/2023.08.02.551636

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