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Article

DNA methylation down‐regulates integrin β4 expression in asthmatic airway epithelial cells

3 Jul 2020

Abstract excerpt

BACKGROUND: Integrin β4 (ITGB4) is a hemi-desmosome protein which is downregulated in the airway epithelial cells of asthma patients. The proximal promoters and exons of ITGB4 contain CpG islands or multiple CpG sites both in human and mice, which indicated the possible methylation regulation of ITGB4 in airway epithelial cells. OBJECTIVE: We sought to unveil that DNA methylation regulates the decreased ITGB4...

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PMID: 32618381
DOI: 10.1111/cea.13697

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