Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.

Genome medicine - 20 Jul 2020

Thompson Emma E, Dang Quynh, Mitchell-Handley Blair, Rajendran Kavitha, Ram-Mohan Sumati, Solway Julian, Ober Carole, Krishnan Ramaswamy

Abstract excerpt

BACKGROUND: A challenge in the post-GWAS era is to assign function to disease-associated variants. However, available resources do not include all tissues or environmental exposures that are relevant to all diseases. For example, exaggerated bronchoconstriction of airway smooth muscle cells (ASMCs) defines airway hyperresponsiveness (AHR), a cardinal feature of asthma. However, the contribution of ASMC to genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bronchial Hyperreactivity

Share to Cytokines

Share to Disease Susceptibility

Share to DNA Methylation

Share to Myocytes, Smooth Muscle

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 32690065
DOI: 10.1186/s13073-020-00759-w
PMCID: PMC7370514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.PMID 32690065Read ↗

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort.Semantic proximity Read ↗

Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma.Semantic proximity Read ↗

A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohortsSemantic proximity Read ↗

Genetic susceptibility to obesity-related asthma and its modulation by sequelae of obesitySemantic proximity Read ↗

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.Semantic proximity Read ↗

Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in AsthmaSemantic proximity Read ↗

Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases.Semantic proximity Read ↗

A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthmaSemantic proximity Read ↗

Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locusSemantic proximity Read ↗

Therapeutic implication of genetic variants of IL13 and STAT4 in airway remodelling with bronchial asthma.Semantic proximity Read ↗

Targeting a central feature of asthma using a cell type-selective IL-13-responsive enhancerSemantic proximity Read ↗

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.