Article

Inhibition of Immunoglobulin E Attenuates Pulmonary Hypertension

2021-11-04

Abstract excerpt

Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by pathological vascular remodeling in the lung. Immunoglobulin E (IgE) is known to participate in aortic vascular remodeling, but whether IgE mediates pulmonary vascular remodeling in PH is unknown. Here, we found serum IgE elevation in PAH patients, hypoxia-induced PH mice and monocrotaline (MCT)-induced PH rats. Combining animal model...

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Literature Corpus work: 4a79fde0-0b54-5255-9610-a23631e9cdb5
DOI: 10.21203/rs.3.rs-1036422/v1

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