Article

IgM regulates airway hyperresponsiveness via modulation of actin associated genes.

2021-10-01

Abstract excerpt

<title>Abstract</title> <p>Allergic asthma is a disease driven by T helper 2 (Th2) cells, eosinophilia, airway hyperresponsiveness (AHR) and IgE-secreting B cells. Asthma is largely controlled by corticosteroids and β2 adregenic receptor agonists that target and relax airway smooth muscle (ASM). Immunoglobulin M (IgM) isotype secreted by naïve B cells is important for class switching but may have other undefined...

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Literature Corpus work: fc1a1615-ddee-53d5-b7e2-c3431758f607
DOI: 10.21203/rs.3.rs-891683/v1

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