Article

Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouse

2021-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Although immunoglobulin class-switching is essential for humoral immunity, its role in B-cell immune tolerance remains unclear. Pemphigus vulgaris is an autoimmune blistering disease caused by IgG targeting desmoglein 3, an adhesion molecule of keratinocytes. In this study, we generated knock-in mice that express anti-Dsg3 AK23 autoantibodies. Knock-in B cells developed normally in vivo and sho...

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Literature Corpus work: ed3f82c6-a378-5f29-a24e-039ac80b07b7
DOI: 10.1101/2021.05.23.445300

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