Article
Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.
The European respiratory journal - 1 May 2024
Liu Tao, Liu Siqi, Rui Xianliang, Cao Ye, Hecker Julian, Guo Feng, Zhang Yihan, Gong Lu, Zhou Yihan, Yu Yuzhen, Krishnamoorthyni Nandini, Bates Samuel, Chun Sung, Boyer Nathan, Xu Shuang, Park Jin-Ah, Perrella Mark A, Levy Bruce D, Weiss Scott T, Mou Hongmei, Raby Benjamin A, Zhou Xiaobo
Abstract excerpt
RATIONALE: Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction of interferon-stimulated genes (ISGs). How asthma-susceptibility genes modulate cellular response upon viral infection by fine-tuning ISG induction and subsequent airway inflammation in genetically susceptible asthma patients remains largely unknown. OBJECTIVES: To decipher the...
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