Article
GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2016
Das Sudipta, Miller Marina, Beppu Andrew K, Mueller James, McGeough Matthew D, Vuong Christine, Karta Maya R, Rosenthal Peter, Chouiali Fazila, Doherty Taylor A, Kurten Richard C, Hamid Qutayba, Hoffman Hal M, Broide David H
Abstract excerpt
Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly expressed in lung bronchial epithelium in human asthma. Overexpression of GSDMB in primary human bronchial epithelium increased expression of genes important to both airway remodeling [TGF-β1, 5-lipoxygenase (5-LO)] and airway-hyperresponsiveness...
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