Article

Impaired clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in a mouse model of Alzheimer’s disease

2021-02-13

Abstract excerpt

<h4>ABSTRACT</h4> Patients with Alzheimer’s disease (AD) often have fragmentation of sleep/wake cycles and disrupted 24-h (circadian) activity. Despite this, little work has investigated the potential underlying day/night disruptions in cognition and neuronal physiology in the hippocampus. The molecular clock, an intrinsic transcription-translation feedback loop that regulates circadian behavior, may also regulat...

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Literature Corpus work: 0ef2ae9c-2afc-5ca3-8752-ff93a488c346
DOI: 10.1101/2021.02.12.430852

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