Back to search

Article

Cardiomyocyte-expressed TGFβ signals to fibroblasts to program early heart maturation and adult myocyte identity

2025-09-22

Abstract excerpt

Transforming growth factor β (TGFβ) is a secreted growth factor that is sequestered to the extracellular matrix (ECM) as a latent complex. In adult disease TGFβ release in the heart transforms fibroblasts into a differentiated state that synthesizes more ECM. However, it is not known how TGFβ functions in the early developing heart to impact resident fibroblasts. Here, we observe that deletion of the Tgfb1 , Tgf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f22e62bc-6201-5718-b475-5abe06b60b86
DOI
10.1101/2025.09.22.677845
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cardiomyocyte-expressed TGFβ signals to fibroblasts to program early heart maturation and adult myocyte identityDOI 10.1101/2025.09.22.677845
Cardiac fibroblasts regulate cardiomyocyte hypertrophy through dynamic regulation of type I collagenSemantic proximity
The TGFβ superfamily in cardiac dysfunctionSemantic proximity
Cardiomyocyte-fibroblast crosstalk in the postnatal heartSemantic proximity
Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosisSemantic proximity
Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblastsSemantic proximity
The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity
Consequences of PDGFRα <sup>+</sup> fibroblast reduction in adult murine heartsSemantic proximity
TGF-β signaling in health and diseaseSemantic proximity
HCM-associated mutations in MYH6/7 drive pathologic expression of TGF-β1 in cardiomyocytes within weeks of developmental specificationSemantic proximity
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathySemantic proximity
The ECM as a driver of heart development and repairSemantic proximity
Cardiac Fibroblast DiversitySemantic proximity
Select a neighboring publication to make it the new centre.