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Article

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

16 Apr 2018

Abstract excerpt

Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts. Here, we employed 3 different mouse lineage-tracing models and stage-specific gene profiling...

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PMID: 29664017
DOI: 10.1172/jci98215

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