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Article

Myofibroblast-mediated mechanisms of pathological remodelling of the heart.

Nature reviews. Cardiology - 1 Jan 2013

Weber Karl T, Sun Yao, Bhattacharya Syamal K, Ahokas Robert A, Gerling Ivan C

Abstract excerpt

The syncytium of cardiomyocytes in the heart is tethered within a matrix composed principally of type I fibrillar collagen. The matrix has diverse mechanical functions that ensure the optimal contractile efficiency of this muscular pump. In the diseased heart, cardiomyocytes are lost to necrotic cell death, and phenotypically transformed fibroblast-like cells-termed 'myofibroblasts'-are activated to initiate a...

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Source

Identifiers

PMID: 23207731
DOI: 10.1038/nrcardio.2012.158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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