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Article

Changes in cardiac resident fibroblast physiology and phenotype in aging.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2018

Trial JoAnn, Cieslik Katarzyna A

Abstract excerpt

The cardiac fibroblast plays a central role in tissue homeostasis and in repair after injury. With aging, dysregulated cardiac fibroblasts have a reduced capacity to activate a canonical transforming growth factor-β-Smad pathway and differentiate poorly into contractile myofibroblasts. That results in the formation of an insufficient scar after myocardial infarction. In contrast, in the uninjured aged heart,...

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Identifiers

PMID: 29906228
DOI: 10.1152/ajpheart.00237.2018
PMCID: PMC6737453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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