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Article

Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis.

Circulation - 8 Aug 2017

Molkentin Jeffery D, Bugg Darrian, Ghearing Natasha, Dorn Lisa E, Kim Peter, Sargent Michelle A, Gunaje Jagadambika, Otsu Kinya, Davis Jennifer

Abstract excerpt

BACKGROUND: In the heart, acute injury induces a fibrotic healing response that generates collagen-rich scarring that is at first protective but if inappropriately sustained can worsen heart disease. The fibrotic process is initiated by cytokines, neuroendocrine effectors, and mechanical strain that promote resident fibroblast differentiation into contractile and extracellular matrix-producing myofibroblasts. The...

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PMID: 28356446
DOI: 10.1161/CIRCULATIONAHA.116.026238
PMCID: PMC5548661

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