Article

The human X chromosome in sexual differentiation and reproduction: is the X still “sexy”?

2026-02-05

Abstract excerpt

<h4>ABSTRACT</h4> The X chromosome (chrX) is the eighth largest human chromosome, harbouring an estimated total of 839 protein-coding genes. Historically, the chrX has been described as enriched for genes related to brain development, sexual differentiation and reproduction, earning the epithet of “smart and sexy chromosome”. Many studies have confirmed that the chrX is indeed “smart”, including a recent systemat...

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Literature Corpus work: 8513568b-33b2-5839-90c0-0bea85c164b2
DOI: 10.64898/2026.02.03.703532

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