Structure-based design and characterization of Parkin activating mutations

Abstract excerpt

Human autosomal recessive mutations in the Parkin gene are causal for Parkinson’s disease (PD). Parkin encodes a ubiquitin E3 ligase that functions together with the PD associated kinase, PINK1, in a mitochondrial quality control pathway. Structural studies reveal that Parkin exists in an inactive conformation mediated by multiple autoinhibitory domain interfaces. Here we have performed comprehensive mutational an...

Topics

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• Autophagy in Disease and Therapy
• Gain of Function Mutation
• Mutation
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments
• Rats
• Ubiquitin
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

46cf425a-0010-5120-97c6-50e7864f2699

DOI

10.1101/2022.02.22.481412