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Neural organoids for disease phenotyping, drug screening and developmental biology studies.

Neurochemistry international - 1 Jun 2017

Hartley Brigham J, Brennand Kristen J

Abstract excerpt

Human induced pluripotent stem cells (hiPSCs) can theoretically yield limitless supplies of cells fated to any cell type that comprise the human organism, making them a new tool by which to potentially overcome caveats in current biomedical research. In vitro derivation of central nervous system (CNS) cell types has the potential to provide material for drug discovery and validation, safety and toxicity assays,...

Topics

Animals
Cell Culture Techniques
Developmental Biology
Drug Evaluation, Preclinical
Humans
Induced Pluripotent Stem Cells
Organoids
Pharmaceutical Preparations
Phenotype
Toxicity Tests

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Identifiers

PMID: 27744003
DOI: 10.1016/j.neuint.2016.10.004
PMCID: PMC5389930

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