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Article

miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models.

American journal of human genetics - 8 Aug 2013

Cheng Pei-Hsun, Li Chia-Ling, Chang Yu-Fan, Tsai Shaw-Jeng, Lai Yen-Yu, Chan Anthony W S, Chen Chuan-Mu, Yang Shang-Hsun

Abstract excerpt

Huntington disease (HD) is a dominantly inherited neurodegenerative disorder characterized by dysregulation of various genes. Recently, microRNAs (miRNAs) have been reported to be involved in this dysregulation, suggesting that manipulation of appropriate miRNA regulation may have a therapeutic benefit. Here, we report the beneficial effects of miR-196a (miR196a) on HD in cell, transgenic mouse models, and human...

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Identifiers

PMID: 23810380
DOI: 10.1016/j.ajhg.2013.05.025
PMCID: PMC3738820

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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