Article

Scn4b Modulates Huntington’s Disease Phenotype Severity in vivo

2026-03-10

Abstract excerpt

<h4>SUMMARY</h4> Although it has been known for over 30 years that CAG trinucleotide repeat expansions in the HTT gene are the cause of Huntington’s disease (HD), it is still not understood how these mutations lead to the loss of striatal spiny projection neurons (SPNs) and other vulnerable neuronal cell types in HD. Here we show that SCN4B , a gene that is enriched in neurons that influence motor function, inc...

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Literature Corpus work: 0ee6914a-a11e-5431-9dfd-6d26e4caaa72
DOI: 10.64898/2026.03.08.708251

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