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Article

SARS-CoV-2-Encoded MiRNAs Inhibit Host Type I Interferon Pathway and Mediate Allelic Differential Expression of Susceptible Gene.

Frontiers in immunology - 1 Jan 2021

Zhu Youwei, Zhang Zhaoyang, Song Jia, Qian Weizhou, Gu Xiangqian, Yang Chaoyong, Shen Nan, Xue Feng, Tang Yuanjia

Abstract excerpt

Infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the rapid spread of coronavirus disease 2019 (COVID-19), has generated a public health crisis worldwide. The molecular mechanisms of SARS-CoV-2 infection and virus-host interactions are still unclear. In this study, we identified four unique microRNA-like small RNAs encoded by SARS-CoV-2. SCV2-miR-ORF1ab-1-3p and...

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Identifiers

PMID: 35003084
DOI: 10.3389/fimmu.2021.767726
PMCID: PMC8733928

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