Article

SARS-CoV-2 selectively induces the expression of unproductive splicing isoforms of interferon, class I MHC and splicing machinery genes

2023-04-13

Abstract excerpt

Splicing is a highly conserved, intricate mechanism intimately linked to transcription elongation, serving as a pivotal regulator of gene expression. Alternative splicing may generate specific transcripts incapable of undergoing translation into proteins, designated as unproductive. A plethora of respiratory viruses, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), strategically manipulate t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 487bb3bf-f4c4-5631-9def-74ff33404366
DOI: 10.1101/2023.04.12.536671

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 selectively induces the expression of unproductive splicing isoforms of interferon, class I MHC and splicing machinery genesDOI 10.1101/2023.04.12.536671Read

SARS-CoV-2 Selectively Induces the Expression of Unproductive Splicing Isoforms of Interferon, Class I MHC, and Splicing Machinery GenesSemantic proximity Read

Variant- and Vaccination-Specific Alternative Splicing Profiles in SARS-CoV-2 InfectionsSemantic proximity Read

Alternative splicing broadens antiviral diversity at the human <i>OAS2</i> locusSemantic proximity Read

Long-read single-cell RNA sequencing uncovers cell-type specific transcript regulation in COVID-19Semantic proximity Read

Betacoronavirus-specific alternate splicingSemantic proximity Read

Ribosome-Profiling Reveals Restricted Post Transcriptional Expression of Antiviral Cytokines and Transcription Factors during SARS-CoV-2 InfectionSemantic proximity Read

Ribosome-profiling reveals restricted post transcriptional expression of antiviral cytokines and transcription factors during SARS-CoV-2 infectionSemantic proximity Read

Rapid Decay of Host Basal mRNAs During SARS-CoV-2 Infection Perturbs Host Antiviral mRNA Biogenesis and ExportSemantic proximity Read

Omicron-Enhanced Immunosuppressive Effects of SARS-CoV-2 ORF3a and ORF9b Accessory Proteins on Monocytic Inflammatory ResponseSemantic proximity Read

Direct RNA Sequencing Reveals m6A Modifications and Isoform Changes in SARS-CoV-2-Infected HEK CellsSemantic proximity Read

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axisSemantic proximity Read