Article
Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories.
Nature communications - 21 Aug 2024
Gezsi Andras, Van der Auwera Sandra, Mäkinen Hannu, Eszlari Nora, Hullam Gabor, Nagy Tamas, Bonk Sarah, González-Colom Rubèn, Gonda Xenia, Garvert Linda, Paajanen Teemu, Gal Zsofia, Kirchner Kevin, Millinghoffer Andras, Schmidt Carsten O, Bolgar Bence, Roca Josep, Cano Isaac, Kuokkanen Mikko, Antal Peter, Juhasz Gabriella
Abstract excerpt
The heterogeneity and complexity of symptom presentation, comorbidities and genetic factors pose challenges to the identification of biological mechanisms underlying complex diseases. Current approaches used to identify biological subtypes of major depressive disorder (MDD) mainly focus on clinical characteristics that cannot be linked to specific biological models. Here, we examined multimorbidities to identify...
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